Efficacy and safety of direct oral anticoagulants in pediatric congenital and acquired heart disease: a systematic review and meta-analysis of randomized controlled trials.

Thromb J · 2026 · PMC13123206 · PMID 42032668

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showed a trendno p-value reported

In the pooled analysis, DOACs showed a trend toward fewer DVTs, but this did not reach statistical significance.

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did not reach statistical significanceno p-value reported

In the prespecified congenital heart disease (CHD) subgroup, a trend toward reduced events was observed but did not reach statistical significance (RR = 0.29, 95% CI: 0.06–1.29).

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