Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Improves Colonic Barrier Function and Mast Cell Activation in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: A Mechanistic Trial.

Although most of the variables remained significant for responders as in the initial analysis, several key physiological parameters that were initially nonsignificant in the nonresponder group (using a 100-point cutoff) were now either significant or approached significance.

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Compared with baseline, cumulative 8- to 24-hour lactulose excretion and 8- to 24-hour lactulose to mannitol ratio (LMR) also decreased post-LFD among the responders, but these did not reach statistical significance ( Figure 2A ).

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