did not reach statistical significancep = 0.0659
We observed a trend toward reduced connectivity at P56 that did not reach statistical significance ( Fig. 5 D , right, P17: 4.17 ± 0.87 out of 8 ROIs, P56: 2.3 ± 0.9 out of 8 ROIs; U = 18.5, p = 0.0659, Mann–Whitney U test).