Renin-angiotensin imbalance promotes excessive fibrin deposition through M2 macrophage-derived tissue factor expression in eosinophilic chronic rhinosinusitis.

Inflamm Res · 2026 · PMC13124779 · PMID 42050086

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showed a trendno p-value reported

Semi-quantitative analysis showed a trend toward increased AT1R expression in ECRS NP compared to non-ECRS NP.

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did not reach statistical significanceno p-value reported

Some parameters, including tissue angiotensin II levels, did not reach statistical significance, and a larger sample size may be necessary to confirm these findings.

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an increasing trendno p-value reported

We found an increasing trend in angiotensin II levels and significantly decreased Ang-(1–7) levels in ECRS NP tissues compared with non-ECRS NP tissues, likely due to reduced ACE2 expression (Fig. 2 ).

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