Hypocretin receptor 1 blockade early in abstinence prevents incubation of cocaine seeking and normalizes dopamine transmission.

Neuropsychopharmacology · 2026 · PMC13125265 · PMID 41639572

Europe PMC DOI

hedged sentences

0.0504

closest p · 1.0× alpha

0.0639

boldest claim

The sentences

a strong trendp < 0.0504so close (0.05 < p ≤ 0.1)

Notably, incubated rats did not differ from non-incubated rats on AD1 pressing ( p < 0.1411) and while non-incubated rats did not significantly reduce lever pressing between AD1 and AD8, there was a strong trend for significance ( p < 0.0504).

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showed a trendp < 0.0639so close (0.05 < p ≤ 0.1)

Holm-Bonferroni tests revealed that Hcrtr1 antagonism significantly reduced DAT sensitivity to cocaine at the 30 μM cocaine concentration ( p < 0.0293), showed a trend for reduced effects at the 10 μM concentration ( p < 0.0639), but did not affect DAT sensitivity at other concentrations (0.3 μM, p < 0.2966; 1 μM, p < 0.1953; 3 μM, p < 0.2350).

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