Advancements in Glioblastoma Multiforme Treatment: A Comprehensive Systematic Review and Meta-Analysis.

Brain Behav · 2026 · PMC13125373 · PMID 42050865

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a significant trendno p-value reported

3.6.1 PFS and OS Comparison In our comparison of PFS and OS between monotherapy and combined therapy, monotherapy showed a significant trend toward superior PFS and OS.

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marginally significantno p-value reported

Despite the observed heterogeneity across studies, the overall effects for PFS ( Z = 2.14, p = 0.03) and OS ( Z = 1.99, p = 0.05) were marginally significant, suggesting a potential benefit of monotherapy over combined therapy for both survival outcomes.

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showed a trendno p-value reported

Moreover, monotherapy showed a trend toward superior PFS and OS compared with combined therapies, albeit not statistically significant, suggesting the potential of monotherapy to optimize GBM treatment strategies (Yamaguchi et al. 2021 ).

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