Barely Significant
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Efficacy and Safety of Laser-Based Therapies for Melasma: A Systematic Review and Meta-Analysis.

Cureus · 2026 · PMC13128289 · PMID 42064496

Europe PMCDOI
3
hedged sentences
0.2682
closest p · 5.4× alpha
0.2682
boldest claim

The sentences

showed a trendp = 0.2682not close (p > 0.1)
The overall pooled analysis showed a trend toward clinical improvement that was not statistically significant (MD: 0.70; 95% CI: -0.55, 1.95; p = 0.2682).

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a positive trendno p-value reported
failed to reach significanceno p-value reported
Fractional lasers: Data from eight trials showed a pooled MD of 0.94 (95% CI: -0.84, 2.71, p > 0.05), indicating a positive trend that failed to reach significance.

also in 11,005 other papers

did not reach statistical significanceno p-value reported
While a trend toward clinical improvement was observed, the results did not reach statistical significance in the overall cohort.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.