Comparative Efficacy and Safety of Osteobiologics in Posterior Lumbar Fusion: A Network Meta-Analysis of Randomized Controlled Trials.

Global Spine J · 2026 · PMC13128799 · PMID 42054700

Europe PMC DOI

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failed to reach statistical significanceno p-value reported

14 Using this approach, our recent NMA 15 identified rhBMP-2 as the osteobiologic with the most consistent evidence for improved fusion and safety compared with AICBG, while other osteobiologics failed to reach statistical significance.

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did not reach statistical significanceno p-value reported

Other osteobiologics showed favourable trends in fusion and safety outcomes, and achieved moderate to high SUCRA rankings, but these differences did not reach statistical significance.

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