Exploratory association between multimodal AI-derived digital biomarkers and in-hospital mortality in adult patients with pneumonia: A proof-of-concept study.

PLOS Digit Health · 2026 · PMC13132438 · PMID 42060654

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

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boldest claim

The sentences

a trend toward significancep = 0.070so close (0.05 < p ≤ 0.1)

A general diagnosis of pneumonia showed a trend toward significance (OR 3.62, 95% CI 0.94–13.87, p = 0.070).

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approached significanceno p-value reported

In the beat-level LMM, only RR-interval features approached significance ( q = 0.068), consistent with tachycardia as a marker of physiological stress in acute illness [ 33 ].

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did not reach statistical significanceno p-value reported

Other factors, including individual bilateral lung compromise ratios (right: OR 1.36, p = 0.23; left: OR 0.84, p = 0.50), NLP-extracted age, sex, and other principal diagnoses, did not reach statistical significance.

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