Automated high-throughput quantification of plasma p-tau217 and APOE-ε4 for Alzheimer's disease diagnosis and cognitive decline in a memory cohort.

Cognitive decline and p-tau217 Among AD patients with longitudinal follow-up ( n = 69; median follow up 2.1 years), higher baseline plasma Elecsys p-tau217 levels were associated with lower MoCA scores at baseline and showed a trend toward faster cognitive decline over time ( p = 0.07) in models adjusted for age and sex.

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While this longitudinal association did not reach statistical significance, the direction of effect is consistent with emerging longitudinal evidence linking higher p-tau217 to subsequent cognitive worsening and increasing tau burden over time [ 31 – 33 ].

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