Fluoxetine attenuates UPR-activation, neuroinflammation, and oxidative stress in a nitroglycerin-induced rat model of migraine.

A notable and unexpected finding was that prophylactic fluoxetine co-administered with NTG showed a trend toward exacerbating light-avoidance behavior, specifically by increasing the latency to enter the light chamber.

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While this observation did not reach statistical significance in our study, it contrasts with some reports of antioxidant depletion in migraine and could be explored in future work as a potential adaptive response to oxidative challenge ( 40 ).

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