Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.

Clin Oral Investig · 2026 · PMC13136227 · PMID 42071113

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Although this difference did not reach statistical significance in multivariate analysis, it may further support the favorable biological response to extruded calcium silicate–based materials.

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showed a trendno p-value reported

Similarly, sex, arch location, and tooth type did not significantly influence healing, although molars showed a trend toward lower success at 2 and 3 years.

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