Decoding drug-responsive cell subpopulations in triple-negative breast cancer using single-cell multiomics.

Specifically, subpopulation F1-and-F2-mixture, distinguished by both high hypoxia and immune suppressive genes, showed a trend toward better overall survival compared with other subpopulations.

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While these observations did not reach statistical significance, they suggest that subpopulation-specific transcriptional identities may capture biologically meaningful heterogeneity with potential relevance to patient outcomes.

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