Multiplexed Imaging Reveals Immune-Metabolic Niches in Multiple Myeloma Linked to Progression and Bone Disease.

In contrast, the median level of PC abundance near OB/RUNX2 + cells tended to be lower in patients with BD, although the overall difference between cohorts did not reach statistical significance ( Fig. 3F ).

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This spatial enrichment was independent of overall PC abundance and showed a clear trend toward lower PC density in the vicinity of OCs in patients without BD ( Fig. 3E ), although it did not reach conventional statistical significance ( P = 0.063; Fig. 3E ; Supplementary Fig.

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