Evidence for early endothelial dysfunction associated with the ALDH2 rs671 gene variant: A preliminary investigation with young East Asians.

Exp Physiol · 2026 · PMC13140734 · PMID 41364906

Europe PMC DOI

hedged sentences

0.0790

closest p · 1.6× alpha

0.0790

boldest claim

The sentences

approached significanceP = 0.079so close (0.05 < p ≤ 0.1)

Carriers displayed lower FMD, either absolute or relative, which was not statistically significant but approached significance (unpaired t ‐test) (FMD%: non‐carriers = 10.2 ± 1.9% vs. carriers = 8.1% ± 3.1%, P = 0.079, effect size: Cohen's d = 0.82; FMD abs : non‐carriers = 0.32 ± 0.06 mm vs. carriers = 0.26 ± 0.09 mm, P = 0.082, effect size: Cohen's d = 0.78).

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did not reach statistical significanceno p-value reported

The difference is physiologically relevant, but did not reach statistical significance.

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