Barely Significant
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Clinical Outcomes of Lobular Carcinoma <i>In Situ</i>: Risk of Invasive Cancer Development.

J Breast Cancer · 2026 · PMC13144646 · PMID 41918186

Europe PMCDOI
2
hedged sentences
0.0640
closest p · 1.3× alpha
0.0640
boldest claim

The sentences

showed a trendp = 0.064so close (0.05 < p ≤ 0.1)
However, pleomorphic LCIS showed a trend toward an increased risk of invasive cancer compared to classic LCIS (HR, 3.856; 95% CI, 0.922–16.126; p = 0.064).

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did not reach statistical significanceno p-value reported
In contrast, pleomorphic LCIS showed a 3.856-fold higher risk of invasive cancer development than classic LCIS (HR, 3.856; 95% CI, 0.922–16.126; p = 0.064), indicating a trend toward increased risk, although the result did not reach statistical significance ( Table 4 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.