Therapeutic potential of cAMP-mediated lysosomal pH modulation in ATP6V1B2-related neuropathology.

While p62 accumulation did not reach statistical significance, the observed reduction in mature Cathepsin D coupled with marked LAMP1 upregulation in homozygous mice provide complementary evidence supporting autophagic flux impairment and associated lysosomal dysfunction in this model (Fig. 8A, B ).

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While Rapamycin and Teprenone showed marginal pH improvement trends in heterozygous cells, their effects failed to reach statistical significance compared to untreated controls.

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