Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation.

Interestingly, we observed an increase in the proportion of EdU-positive alpha cells following harmine treatment (Figure S5); however, as with beta cells, this increase did not reach statistical significance.

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While co-culture of islets with M(IL-4, IL-13) macrophages or treatment with harmine alone showed a trend toward increased beta cell proliferation, a significant effect in both mouse and human beta cell proliferation was observed only when the two were combined.

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