Drp1 regulates mitochondrial health and controls skeletal muscle mass through the Erk1/2-Nur77 pathway.

In contrast, the cytosolic fraction showed a modest upward trend that did not reach statistical significance ( Fig. 4, B and C ).

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Treatment of wild-type (WT) mice with Clen in drinking water for 1 week significantly increased lean mass, particularly in the gastrocnemius muscle, up-regulated Nur77 gene expression and protein level ( P = 0.0871), and showed a trend toward reduced Atrogin-1 expression, accompanied by a marked increase in Erk1/2 phosphorylation in gastrocnemius muscles ( Fig. 8, A to D , and fig.

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