Barely Significant
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Real-world efficacy, safety, and associated biomarkers of cadonilimab in cervical cancer: a prospective observational study.

Front Immunol · 2026 · PMC13158195 · PMID 42125658

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0.0500
closest p · 1.0× alpha
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boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant
Furthermore, we observed a trend toward a higher incidence of AEs in patients with a lower baseline CD3 + CD4 + /CD3 + CD8 + ratio during cadonilimab treatment, although this trend did not reach statistical significance (p > 0.05).

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showed a trendno p-value reported
Additionally, ethnic minority status and low baseline CD3 + levels showed a trend toward higher ORR in univariate logistic regression analysis, though without statistical significance, warranting further validation through long-term follow-up.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.