A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research.

Clin Transl Sci · 2026 · PMC13158523 · PMID 42108728

Europe PMC DOI

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showed a trendno p-value reported

Four participants showed a trend toward reduced Opiate Withdrawal Checklist (OWC) scores over time, suggesting symptomatic improvement, while the remaining six showed no notable change.

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a nonsignificant trendno p-value reported

In contrast, when given during acute withdrawal, BTMPS produced only a nonsignificant trend toward OWSx reduction.

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did not reach statistical significanceno p-value reported

Neonates randomized to chlorpromazine and phenobarbital required a median of 3 and 10 additional treatment days, respectively, compared to morphine; however, these differences did not reach statistical significance.

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