Highly significant group effects emerged for FC between the LN and peak coordinates within the MDTB7 (R_MDTB7-LN FC; F (2,152) = 13.27, p < 0.001, η 2 = 0.15), MDTB8 (R_MDTB8-LN FC; F (2,152) = 22.94, p < 0.001, η 2 = 0.23), and MDTB9 (R_MDTB9-LN FC; F (2,152) = 32.80, p < 0.001, η 2 = 0.30).
This analysis partially replicated our findings: we observed a strong trend for R_MDTB9-LN FC ( F (1,39) = 4.06, p = 0.051, η 2 = 0.09) and R_Crus II volume ( F (1,39) = 4.57, p = 0.039, η 2 = 0.11), though these did not survive correction, while R_MDTB8-LN FC ( F (1,39) = 0.36, p = 0.550, η 2 = 0.01) did not differ significantly ( Fig. 7 B-C, Supplementary Fig.
This alternative pathway failed to reach statistical significance (R_Crus II volume → R_MDTB8-LN FC → AQ: β = 0.05, SE = 0.05, 95% CI [-0.05, 0.17]; R_Crus II volume → R_MDTB9-LN FC → AQ: β = 0.01, SE = 0.04, 95% CI [-0.05, 0.10]; Supplementary Table S13 ), which is consistent with the observed pattern in our primary mediation analysis. 3.6 Sensitivity analysis 3