IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8<sup>+</sup> T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression.

p16 INK4a expression showed a decreasing trend (Figure 3H ), correlating positively with CD27 − CD28 − cell proportion (Pearson r = 0.838, p = 0.005; Figure 3I ).

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Granzyme B expression showed a trend toward increase in the combination group (Figure 3C,D ).

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However, this difference did not reach statistical significance for PI3K‐p110 levels (Figure 6C,D ).

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