Circulating plasma protein biomarkers associated with risk of negative clinical outcomes in virally suppressed people with HIV receiving medications for opioid use disorder.

The MET group showed a trend toward lower alcohol impact probability (median predicted probability 0.3 vs. 0.47 in the control group, p = 0.265), consistent with a proteomic signature associated with reduced heavy alcohol consumption ( Table 2 ; Supplementary Table S3 ).

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Other SomaSignal-derived outcomes, such as liver fat, glucose tolerance, and cardiovascular risk factors, did not reach statistical significance in the Kruskal–Wallis test ( Table 2 ), despite showing differences between groups.

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