Clinical Significance of Plasma Sphingosine-1-Phosphate Decline in Progression of Spinal and Bulbar Muscular Atrophy.

J Clin Neurol · 2026 · PMC13161591 · PMID 42108848

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did not reach statistical significanceno p-value reported

In contrast, both the follow-up S1P concentrations and the 3-year changes in S1P exhibited weak positive correlations with ALSFRS-R scores ( r =0.317, p =0.162 and r =0.316, p =0.163, respectively), although these did not reach statistical significance.

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a negative trendno p-value reported

Longitudinal changes in plasma S1P showed weak-to-moderate positive trends with clinical measurements, including ALSFRS-R, FVC, and 6MWT, and a negative trend with serum CK at follow-up.

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