Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer's disease transgenic and wildtype rats.

Fluids Barriers CNS · 2026 · PMC13162435 · PMID 42106823

Europe PMC DOI

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nominally significantp < 0.05actually significant

Nominally significant three-way interaction terms ( p < 0.05) were identified for s-methylcysteine, alpha-aminobutyric acid, and asparagine.

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showed a trendno p-value reported

In contrast, at 50 weeks , female TgF344-AD rats displayed decreases in several amines including DL-3-aminoisobutyric acid, gamma-aminobutyric acid, ornithine, and putrescine, while 50-week male TgF344-AD rats showed a trend towards increased methionine sulfone level compared to 50-week male WT rats.

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