Barely Significant
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Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

J Clin Med · 2026 · PMC13163981 · PMID 42123291

5
hedged sentences
0.0010
closest p · 0.0× alpha
0.1000
boldest claim

The sentences

highly significantp < 0.001actually significant
Age itself showed a strong, highly significant negative association with DMFT in all models ( β around −1.1, p < 0.001), indicating that, within this caries group, younger children tended to have higher DMFT scores.

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borderline significantp = 0.0496actually significant
AISI showed a borderline significant negative association with DMFT ( β = −0.001, 95% CI −0.001 to 0.010, p = 0.0496), while SIRI, SII, NEU, IIC, and NLR showed similar negative trends with p -values between 0.05 and 0.10.

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borderline significancep < 0.10so close (0.05 < p ≤ 0.1)
The analysis proceeded in a stepwise manner, beginning with age- and sex-adjusted univariate regression models for each inflammatory parameter, followed by a multivariable model including biomarkers that demonstrated at least borderline significance ( p < 0.10) in univariate testing.

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Several additional parameters showed borderline differences (0.05 < p < 0.10), including IIC, MCV, dNLR, SII, and SIRI, suggesting potential trends that did not reach statistical significance in this cohort.

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showed a trendno p-value reported
The composite index IIC showed a trend toward higher values in the caries group, although this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.