Cumulative Incidence in Monogenic Alzheimer's Disease and Frontotemporal Dementia: Gene-Gene Interaction Effect.

Int J Mol Sci · 2026 · PMC13164024 · PMID 42123659

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showed a trendno p-value reported

Higher AD-risk-weighted burden scores in AD-related genes were associated with a significantly increased cumulative incidence of AD, while higher FTD-risk-weighted scores in FTD-related genes showed a trend toward association with increased cumulative incidence of FTD.

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did not reach statistical significanceno p-value reported

Using the cross-validated scores, the interaction term in the full model did not reach statistical significance, while the model including AD and FTD scores (AD+FTD) provided the AIC among the tested models.

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