Associations Between OPN-CD44 Axis Genetic Variability, Plasma Osteopontin, and Treatment Outcomes in Head and Neck Squamous Cell Carcinoma.

Int J Mol Sci · 2026 · PMC13164495 · PMID 42123308

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

borderline significantp = 0.061so close (0.05 < p ≤ 0.1)

However, in the RT-only subgroup, this association was only borderline significant ( p = 0.061). 2.5.

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did not reach statistical significancep = 0.061so close (0.05 < p ≤ 0.1)

The CD44 rs13347 T allele carriers had better MFS than CC homozygotes, but the difference did not reach statistical significance ( p = 0.061).

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showed a trendno p-value reported

The OPN rs11730582 SNP showed a trend towards association with OS and LRFS, but these did not reach statistical significance in the full model ( p = 0.076 and 0.078, respectively).

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