Human Milk Oligosaccharide LNnT Attenuates Colonic Barrier Dysfunction and Associated Cognitive Impairment via Modulating Sphingolipid Metabolism and Gut Microbiota.

Although GOS also significantly reduced MDA levels ( p < 0.001) and enhanced SOD activity ( p < 0.05), its effects on CAT and GPx activities failed to reach statistical significance.

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LNnT and GOS interventions reversed these alterations by increasing Lactobacillus abundance and decreasing the abundances of Staphylococcus , Corynebacterium , Aerococcus , and Rummeliibacillus relative to the D-gal group, though the increase in Lactobacillus in the GOS group did not reach statistical significance ( Figure 4 F,G).

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