Evaluating the antidepressant effects of tirzepatide on unpredictable chronic mild stress-induced depression in Swiss Albino mice.

Tzu Chi Med J · 2026 · PMC13167083 · PMID 42131414

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a clear trendno p-value reported

Although our study did not detect a statistically significant reduction in whole-brain IL-6 levels, a clear trend toward normalization was observed in the tirzepatide- and fluoxetine-treated groups.

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did not reach statistical significanceno p-value reported

However, these differences did not reach statistical significance [ Table 2 ].

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