Non-invasive prediction of prognostic immune subtypes in lung adenocarcinoma using PET/CT-based radiomics.

In the TKI-treated cohort (n=118), the subtypes showed a clear trend towards prognostic stratification (log-rank p-value =0.041; Figure 5E ).

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Although this trend did not reach statistical significance after correction, possibly due to sample size, this reversal is generating a hypothesis and consistent with the notion that EGFR-mutant NSCLCs typically present with low tumour mutational burden and a less inflammatory tumour microenvironment ( 32 , 33 ).

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