Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective.

Front Immunol · 2026 · PMC13168026 · PMID 42136641

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.1560

boldest claim

The sentences

a near-significant trendp = 0.07so close (0.05 < p ≤ 0.1)

Consistently, both antibodies elevated ADPR production in MM cells, with DARA reaching statistical significance (p = 0.03) and ISA showing a near-significant trend (p = 0.07).

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did not reach statistical significancep = 0.156not close (p > 0.1)

INO concentrations in BM plasma showed modest increases across treatment phases: PRE-START (mean ± SD: 26.79 ± 14.91 μM; range: 18.64-53.10 μM) and DARA treatment failure (mean ± SD: 28.85 ± 7.31 μM; range: 15.25-25.10 μM), although this difference did not reach statistical significance (p = 0.156) ( Figure 4A ).

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