Sensitivity and prognostic significance of circulating tumor DNA (ctDNA) in stage I to III malignant melanoma.

J Cancer Res Clin Oncol · 2026 · PMC13168401 · PMID 42104999

Europe PMC DOI

hedged sentences

0.0790

closest p · 1.6× alpha

0.0790

boldest claim

The sentences

did not reach statistical significancep = 0.079so close (0.05 < p ≤ 0.1)

Cox-Regression analysis showed a hazard ratio of 2.56 (95% CI, 0.90 to 7.31) although these results did not reach statistical significance ( p = 0.079).

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showed a trendno p-value reported

The correlation of ctDNA detection and OS showed a trend in a negative effect of ctDNA positivity on survival, although these findings did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.