Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.

CNS Neurosci Ther · 2026 · PMC13170474 · PMID 42126345

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

At the 3‐month follow‐up, although the difference did not reach statistical significance, a strong trend toward a higher level of consciousness recovery was noted in the esketamine group than in the propofol group ( t = −2.02, p = 0.06).

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a trend toward significancep = 0.062so close (0.05 < p ≤ 0.1)

Gamma‐band wPLI was independently associated with improved recovery (aOR per 0.1 increase = 2.10; 95% CI: 1.12–3.94; p = 0.021), while PE showed a trend toward significance (aOR per 0.1 increase = 1.45; 95% CI: 0.98–2.15; p = 0.062).

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a strong trendno p-value reported

Compared to propofol, esketamine facilitates superior neurophysiological preservation and shows a strong trend toward improved long‐term clinical outcomes. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Revised 2026 Mar 20; Received 2025 Dec 18; Accepted 2026 Apr 10; Collection date 2026 May. 1.

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