Incidence and Prognostic Value of TP53, STK11, and KEAP1 Mutations Between <i>De Novo</i> Versus Recurrent Actionable Mutation-Negative Non-Small Cell Lung Cancer: A Single-Center Retrospective Study.

However, near-significant associations were noted for KEAP1 mutations in de novo cases and TP53 mutations in recurrent disease, suggesting that the prognostic relevance of these alterations may reflect intrinsic tumor biology and potentially dynamic molecular evolution over the disease course.

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In the de novo group, TP53 and STK11 mutation statuses were not associated with significant differences in PFS and OS, while KEAP1 mutation showed a trend toward longer OS and PFS, approaching statistical significance (P = 0.06) ( Figs. 4a and 5a ).

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