Association between leukotriene receptor antagonists and neuropsychiatric disorders: a systematic review and meta-analysis.

Front Pharmacol · 2026 · PMC13171479 · PMID 42147306

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did not reach statistical significanceno p-value reported

Although these results did not reach statistical significance, all point estimates exceeded zero (RR > 0), suggesting potential elevated risks that warrant consideration ( Figures 5 – 12 ).

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borderline non-significantno p-value reported

Results A meta-analysis of the 21 included studies revealed a borderline non-significant association between LTRA use and neuropsychiatric risk in the overall population (RR = 1.11, 95% CI: 0.98–1.26).

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