Multi-omics integration of molecular genetics, cytogenetics and immunophenotyping: a novel prognostic model for immune landscape characterization and outcome prediction in Chinese patients with acute myeloid leukemia.

Spearman correlation analysis revealed that CD15 expression was significantly and negatively correlated with the proportion of NK cells among peripheral blood nucleated cells (Spearman r = -0.380, P = 0.004) and showed a borderline significant negative correlation with the percentage of NK cells relative to total lymphocytes (Spearman r = -0.304, P = 0.022).

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However, this did not reach statistical significance ( P = 0.069, Supplementary Figure 2C ).

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Patients with t(8;21)/inv(16) without KIT D816 mutation showed a trend toward better OS than those intermediate without any genetic variants (the 2017 ELN, 2022 ELN, and 2023 CN all classified “genetic variants not classified as favorable or adverse” into the intermediate-risk group, so we defined these as “intermediate without any genetic variants”).

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