Barely Significant
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Melanoma Brain Metastasis, Prognostic Factors, and Survival Outcomes After First Metastatic Line Therapy: A Monocentric Retrospective Study.

Cancer Med · 2026 · PMC13176638 · PMID 42136087

2
hedged sentences
0.1220
closest p · 2.4× alpha
0.1220
boldest claim

The sentences

did not reach statistical significancep = 0.122not close (p > 0.1)
TT was also associated with an increased risk (HR, 6.16 [1.83–20.80]; p = 0.003), whereas single‐agent ICI therapy did not reach statistical significance (HR, 2.59 [0.77–8.67]; p = 0.122).

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showed a trendno p-value reported
Patients with a primary tumor mitotic rate ≥ 6/mm [ 2 ] showed a trend toward a higher risk of BM, but this was not significant (OR, 1.75 [0.89–3.45]; p = 0.104).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.