Alpha2EQ downregulates proinflammatory cytokine and chemokine gene expression in cultured synovial fibroblasts.

Am J Vet Res · 2026 · PMC13176655 · PMID 41468692

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did not reach statistical significanceno p-value reported

The ADAMTS4 expression was downregulated (8.93 ± 3.11 vs 5.13 ± 0.85; P = .0442; adjusted P = .0507) but did not reach statistical significance.

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a clear trendno p-value reported

There was a clear trend toward downregulation of these MMPs in IL-6 HIGH cells (experiment 1); however, high intersubject biologic variability may have precluded detection of significant differences in this small population of horses.

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