Metastatic tropism of molecularly defined clear-cell renal cell carcinoma clusters.

J Clin Invest · 2026 · PMC13178644 · PMID 42138077

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

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boldest claim

The sentences

showed a trendP = 0.05actually significant

The PFS of patients presenting with pancreatic metastases on sunitinib showed a trend toward being significantly higher than for those without pancreatic metastases (HR, 0.52; 95% CI, 0.27–1.01; P = 0.05).

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did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

Although the median PFS of patients with angiogenic clusters on atezolizumab/bevacizumab was longer than that for other molecular clusters, it did not reach statistical significance (12.03 [95% CI, 8.55–27.06] vs. 5.92 [95% CI, 5.03–9.14] months, P = 0.06).

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