Bmal1 Attenuates Collagen-Induced Arthritis by Regulating Macrophage Polarization via Sirt1.

J Inflamm Res · 2026 · PMC13178695 · PMID 42147794

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

In addition, Sirt1 knockdown showed a trend toward a 17.58% increase in the p-p65/p65 ratio compared with the Bmal1 overexpression group, although the difference did not reach statistical significance ( Figure 5D ).

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