Comparison of fractionated versus bolus administration of different doses of hyperbaric bupivacaine combined with opioids in spinal anesthesia for caesarean section - a prospective, randomized, participant-blind clinical trial.

The analysis revealed a highly significant time main effect (F (9,864) = 23.935, p < 0.001, η2 p = 0.2), confirming the expected post-spinal hemodynamic trajectory common to all groups.

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The duration of motor block showed a trend towards being shorter in the reduced-dose fractionated group (Group B: 178 ± 43 min, Group F7: 169 ± 53 min, Group F6: 155 ± 33 min, p = 0.12), though this difference did not reach statistical significance.

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