Bidirectional Mendelian randomization study reveals no causal association between polycystic ovary syndrome and IgA nephropathy.

Other 3 Mendelian randomization methods (maximum likelihood, MR-Egger, and weighted median) did not reach statistical significance (Table 2 ).

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Our estimates showed a trend toward potential association that did not reach significance, suggesting a possible modest causal effect that could not be detected under the current power.

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