Cardiac Electrophysiologic Effects of Different Local Anesthetics in Langendorff-Perfused Rabbit Hearts.

Cardiovasc Toxicol · 2026 · PMC13183750 · PMID 42149351

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a clear trendno p-value reported

Notably, bupivacaine showed a clear trend toward increased ventricular tachycardia episodes (11 of 13 hearts at 1 μM), suggesting that the arrhythmogenic threshold may be approached even at clinically relevant doses.

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did not reach statistical significanceno p-value reported

Ventricular tachycardia episodes slightly increased but did not reach statistical significance (baseline: 1 in 13 hearts; + 0.5 μM: 5 in 13 hearts; + 1 μM: 11 in 13 hearts).

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