Omega-3 polyunsaturated fatty acid exposure and cardiovascular outcomes in dialysis: a systematic review and meta-analysis.

Conclusion In this systematic review and meta-analysis of dialysis-dependent CKD, higher n-3 PUFA exposure through supplementation and baseline circulating levels was associated with fewer cardiovascular events and all-cause mortality, respectively, whereas higher dietary intake showed a trend toward decreased mortality that did not reach statistical significance.

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When pooled using each study’s highest versus lowest intake categories, higher n-3 PUFA intake trended toward lower mortality but did not reach statistical significance (pooled HR 0.92, 95% CI 0.79–1.08; I 2 = 23.6%) ( Figure 4 ).

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