Integrative Transcriptomic Analysis Identifies CXCL12 as a Candidate Hub Gene Associated with CD4⁺ T-Cell Immune Network Remodeling in Secondary Lymphedema.

Further analysis revealed that CXCL12 expression was significantly upregulated in SL tissues, while its classical receptor CXCR4 showed a decreasing trend in CD4+ T cells.

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It is noteworthy that although the proportion of resting CD4+ T cells decreased, the proportion of activated CD4+ T cells increased significantly, indicating that CD4+ T cells as a whole showed a trend of transitioning from a resting to an activated state, suggesting that they underwent functional reprogramming in the lymphedema-associated inflammatory microenvironment.

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The results revealed that only approximately 2% of genes showed significant expression changes following CXCL12 depletion, while the remaining 98% did not reach statistical significance.

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