The EphA3 Antibody Enhances CD47 Antibody-Mediated Phagocytosis by Repolarizing M2-Like Tumor-Associated Macrophages in a Preclinical Model of Recurrent Head and Neck Cancer.

Pathway-level analysis showed a trend toward upregulation of NF-κB/TNF-associated inflammatory genes and STAT1/IFNγ signaling-related genes following EphA3 inhibition (Table S3).

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We additionally performed flow cytometric analysis of tumor-infiltrating CD8+ T cells and observed a trend toward increased CD8+ T-cell infiltration in the combination treatment group; however, this difference did not reach statistical significance ( Supplementary Figure S5 ).

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