Molecular characteristics and metastatic mechanism of patients diagnosed with Krukenberg tumor from gastric cancer.

In addition, a higher CNV burden and TP53 mutation status showed a potential trend toward worse outcomes, although these associations did not reach statistical significance [CNV burden: P=0.14, hazard ratio (HR) =0.46, 95% confidence interval (CI): 0.12–1.72; TP53 mutation: P=0.16, HR =2.03, 95% CI: 0.60–6.88] ( Figure 4E,4F ).

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Importantly, patients harboring TP53 mutations or exhibiting a high burden of CNVs showed a trend toward shorter OS; however, these associations did not reach statistical significance in our cohort, indicating that both may have potential prognostic relevance in KTs, but this observation should be interpreted cautiously and requires validation in larger studies.

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