Single-Cell Sequencing Analysis Reveals Dysregulated Energy Metabolism and Altered Synaptic Connectivity in the Mouse Retina Following Dark Rearing.

Invest Ophthalmol Vis Sci · 2026 · PMC13189203 · PMID 42138518

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showed a trendno p-value reported

Dark-reared retinas exhibited significantly reduced basal respiration and maximal respiration compared with controls, whereas spare respiratory capacity showed a trend toward reduction without reaching statistical significance ( Figs. 4 A–D).

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did not reach statistical significanceno p-value reported

Photopic ERG further showed a declining trend in the LA 3.0 amplitude, although this change did not reach statistical significance (see Supplementary Figs.

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